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A first step towards the definitive treatment for diabetes with insulin-addiction

Posted by Donny Rabu, 26 Desember 2007 0 comments
July 15, 2007 - Diabetes Type I is a conviction without a call for medical monitoring for life. Although salaries have become simpler and less in recent years, they still represent an obstacle, especially for children. The latest study published in the journal "Nature" by Dr. Constantin Polychronakos, director of the department of pediatric endocrinology at the MUHC, in collaboration with Dr. Hakon Hakonarson, director of the Centre for Applied Genomics at the Children's Hospital of Philadelphia (CHOP), is a hope that this situation evolve in the long term to the definitive treatment of this disease.

By using the innovative technology of DNA microchips, high-density, which allows testing 550,000 genes in a single analysis, and Dr. Polychronakos Dr Hakonarson have identified a new gene involved in diabetes type I. So far only 4 genes responsible for this disease were known, they are now 5. "We believe that there are around 15 genes involved in insulin-dependent diabetes, our study has shown that DNA microchips high density are an effective method and we hope to be able to identify all of these genes in a future close "says Dr. Polychronakos, also professor of pediatrics and human genetics at McGill University.

The causes of Type I diabetes are still unclear but it is estimated that 50% are the genetic predisposition. That's why validation of a new analytical method extremely powerful, and the identification of a new gene involved, are of great importance. Anyone who has just been discovered meets with the poetic name of "KIAA0350". Its precise function is not yet known, but it is mainly active in the immune system. This seems consistent as Type I diabetes is an autoimmune disease: the patient's immune system destroys its own cells in the pancreas, insulin-producing them by taking intruses for error.

Knowledge of these genes will move in parallel on two different therapeutic: prevention and treatment. The prevention because it will develop more effective tests for newborns likely to develop diabetes type I. The treatment because "we can draw very specific medicines targeting exactly the effects of the defective gene," predicts Dr. Hakonarson. Such treatments associated with a therapy for regeneration by stem cells, will allow patients to not feel any symptoms of diabetes.

"The prospect is still distant, but it is realistic, and this study is the first step," says Dr. Polychronakos.

This study was funded by the Juvenile Diabetes Research Foundation (JDRF), and Genome Canada.

About:

The Research Institute of the McGill University Health Center (MUHC) is a research center of world renown in the field of biomedical sciences and health care. Based in Montreal, Quebec, it is the basis for the MUHC research, teaching hospital affiliated with the Faculty of Medicine at McGill University. The institute has over 500 researchers, nearly 1000 graduate students and postdoctoral and more than 300 research laboratories devoted to a wide range of areas of research, clinical and basic science. The Research Institute is at the forefront of knowledge, innovation and technology. The Institute's research is closely linked to the clinical programs of the MUHC, which allows patients to benefit directly from scientific knowledge of the most advanced. For more information, see the address www.cusm.ca / research.

The cause of juvenile diabetes is insulin

Posted by Donny 0 comments
Camillo Ricordi, international renowned researcher at the University of Miami and the ISMETT of Palermo, is a sponsor of one of two studies published May 12 on the journal Nature. He explained how was conducted to identify the cause of the most serious diabetes: Type 1 diabetes or juvenile diabetes, which affects the United States on a young 400-500. The existence of a genetic predisposition could not, so far, to explain the onset of the disease.

Camillo Ricordi, internationally renowned researcher at the University of Miami and the ISMETT of Palermo, is a sponsor of one of two studies published May 12 on the journal Nature. He explained how was conducted to identify the cause of the most serious diabetes: Type 1 diabetes or juvenile diabetes, which affects the United States on a young 400-500. The existence of a genetic predisposition could not, so far, to explain the onset of the disease. Researchers at the University of Miami, Harvard (Boston) and Minnesota have understood that the cells of the immune system, for reasons as yet unknown, attacked a portion of the insulin molecule and kill cells that produce ( the beta cells in the pancreas). The body was then stripped of the hormone vital for the control of the metabolism of sugars and for the regulation of blood sugar, and those who fall sick are forced to insulin injections or a new transplant beta cells (Ricordi method) . The cause of the disease is therefore an action of "self", concerning the attack only the insulin made by the patient and not synthetic or foreign. In the second study, mice destined to become diabetic, have been genetically modified so as to be unable to produce their own insulin, which is substituted by a biotech. Guinea pigs, which then grow up without their own insulin, remain to be free from diabetes and do not become ill. This fundamental breakthrough opens the way to new strategies for treatment and prevention

The symptoms and treatment of gestational diabetes

Posted by Donny Selasa, 18 Desember 2007 0 comments

 Diabetes is a disease. It is the body's inability to either produce insulin or to use it properly. It is either in the body's inability to produce insulin or use it properly. Insulin is a hormone the body needs in order to convert starches, sugars, and other foods into energy and is required for your body to function. Insulin is a hormone essential for the body to convert starches, sugars, and other food into energy and it is necessary for your body to function.


 What are the causes of Diabetes? What causes diabetes?
The cause of diabetes ios still a mystery, but researchers now know that genetic factors play a role in whether or not you will develop the disease. The cause of diabetes ios remains a mystery, but researchers now know that genetic factors play a role in whether or not you will develop the disease. The environment can also have an effect. The environment may also have an effect. Some of the factors that place you in the high-risk category include not exercising and being overweight - studies have shown that regular physical activity is able to reduce the occurrence of developing diabetes. Some of the factors that put you in the high-risk category are not exercise and being overweight - Studies have shown that regular physical activity can reduce the incidence of diabetes.


 In the US, more than 20 million children and adults suffer from diabetes, that means an astonishing 7% of the population has the disease! In the United States, more than 20 million children and adults suffer from diabetes, it means an astonishing 7% of the population has the disease! Of those people with diabetes, only 14 million have actually been diagnosed. People with diabetes, only 14 million have been diagnosed. The remaining 6 million are still unaware they have the disease and are doing nothing about it. The remaining 6 million are still unaware they have the disease and do nothing about it.


 Types of Diabetes Type of Diabetes
The four major types of diabetes are: type 1, type 2, gestational, and pre-diabetes. The four major types of diabetes: type 1, type 2, gestational, diabetes and preschoolers.



     * Type 1 diabetes is also referred to as juvenile diabetes and affects a person from childhood. Type 1 diabetes is also known as juvenile diabetes, which affects a person from childhood.
     * Type 2 diabetes is often called adult-onset diabetes. Type 2 is often called adult diabetes. Type 2 diabetes is the most common form of diabetes and generally does not afflict someone until he or she is of adult age. Type 2 is the most common form of diabetes and can strike anyone, until he or she is an adult.
     * Gestational diabetes is a special type of diabetes that affects only pregnant women. Gestational Diabetes is a type of diabetes that affects only pregnant women. Not all pregnant women get gestational diabetes, though it is always a matter of concern when a woman is pregnant. Not all pregnant women get gestational diabetes, but it is always a concern when a woman is pregnant. In addition, gestational diabetes subsidies shortly after the child is born. In addition, the gestational diabetes disappears shortly after the child's birth.
     * Pre-diabetes is diagnosed when a person is in the danger zone of becoming a diabetic.


 Before diabetes is diagnosed when a person is in the area at risk of becoming diabetic.


 


 Getting tested for Diabetes Tests for diabetes
In order to test you for diabetes, a doctor uses either a Fasting Plasma Glucose Test (FPG) or an Oral Glucose Tolerance Test (OGTT). To test you for diabetes, the doctor uses either a test of fasting plasma glucose (FPG) or an Oral Glucose Tolerance Test (OGTT). Both tests are effective in testing for pre-diabetes and diabetes. Both tests were successful in the preselection tests diabetes and diabetes.


 The Fasting Plasma Glucose test is endorsed by the American Diabetes Associaion because it is faster, less expensive, and easier to use than the OGTT test. Fasting plasma glucose test is approved by the American Diabetes Associaion because it is faster, cheaper and easier to use than the OGTT test.


 If you are being tested with the FPG test, you should have a fasting (not eating) blood glucose level between 100 and 125 mg / dl if your body is functioning normally. If you are tested with the FPG test, you must have an empty stomach (not eating) blood sugar between 100 and 125 mg d '/ dl if your body is functioning normally. If you have diabetes you will have a fasting blood glucose level of 126 mg / dl or higher. If you have diabetes you have a level of fasting blood glucose levels of 126 mg / dl or higher.


 With the OGTT test, you needs to fast for two hours after drinking a special glucose-rich drink. With the OGTT test, it needs to fast for two hours after drinking a glass of glucose rich. If your blood glucose level is anywhere from 140 to 199 mg / dl after fasting, you have pre-diabetes. If the blood sugar level is anywhere from 140 to 199 mg d '/ dl after fasting, before you have diabetes. If the level is 200 mg / dl or higher, you will be diagnosed with diabetes. If the level is 200 mg / dl or more, you will be diagnosed with diabetes.
  

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